Clinical Publications

Below is a bibliography of publications about the Paragonix Technologies products and related areas of research.

First Report of the GUARDIAN Registry: An International Consortium Examining the Effect of Controlled Hypothermic Preservation in Heart Transplantation
D.D’Alessandro, J.Philpott, T. Boeve, S. Pham, A. Zuckermann
Presentation at ISHLT 2021

Early Experience with a New Storage Device for Cold Preservation
J. Gökler, P. Angleitner, R. Moayedifar, H. Johann, A. Aliabadi-Zuckermann, G. Laufer, A. Zuckermann.
Poster at ISHLT 2021

Longest Storage Period with Static Hypothermic Preservation in Cardiac Transplantation: Initial Experience in the West Coast
B. A. Guenthart, A. Alassar, T. Koyano, S. La Francesca, J. L. Chan, A. Krishnan, J. W. MacArthur, Y. Shudo, W. Hiesinger, Y. Woo.
Poster at ISHLT 2021

Effect of Donor Heart Preservation Temperature Monitoring Technology on Primary Graft Dysfunction and Outcomes in Heart Transplantation
A. M. Tutunjian, M. Kawabori, T. Nordan, Y. Zhan, F. Y. Chen, K. G. Warner, H. Rastegar, G. S. Couper
Poster at ISHLT 2021

Use of SherpaPak™ CTS for Organ Transportation during Heart Transplantation: First Clinical Use in United Kingdom and Outcomes
V. Mehta, A. Joshi, J. Hasan1, K. Oommen, P. Callan, S. Shaw, R. V. Venkateswaran
Poster at ISHLT 2021

First clinical experience with the novel cold storage SherpaPak™ system for donor heart transportation
D. Radakovic, S. Karimli, J. Penov, I. Schade, K. Hamouda, C. Bening, R. Leyh, I. Aleksic
The Journal of Thoracic Disease, Dec; 12(12): 7227–7235, 2020,

Utilization of New Heart Preservation Technology in the Era of New Organ Allocation and Extended Ischemic Times
M. Funamoto, C.S. Ong, S.E. Kilmarx, S.S. Li, P.J. Spencer, P. Moonsamy, N. Mohan, E.E. Coglianese, G.D. Lewis
R.N. Pierson, M.A. Villavicencio-Theoduloz, D.A. D’Alessandro
The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4, S136, 2020

First Experience with a New Storage Device for Cold Preservation
J. Goekler, A. Zuckermann, P. Angleitner, E. Ceran, P. Kaiser, N. Neuber, J. Horvat, G. Laufer, A. Aliabadi-Zuckermann
The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4, S244, 2020

Cool Static Storage Preservation and Transportation of Donor Hearts: Introducing New Technologies in Latin America: Paragonix SherpaPak™
A. Ameri, N. Bernal Aragon, E. Giordanino, D. Rubira, R. Ratto, L. Favaloro, R. Favaloro, M. Renedo, D. Absi, A. Bertolotti
Presentation at ISHLT 2020

The First Clinical Use of a Novel Cold Storage System of Donor Hearts
N. Naito, M. Funamoto, R. Pierson, M. Villavicencio, W. Riley, G. Lewis, D. D’Alessandro
The Journal of Heart and Lung Transplantation, Vol. 38, Issue 4, S244, 2019

Innovative cold storage of donor organs using the Paragonix Sherpa Pak ™ devices
S.G. Michel, G.M. LaMuraglia II, M.L.L Madariaga, Lisa M. Anderson
Heart, Lung and Vessels. 2015; 7(3): 246-255.

Preservation of Donor Hearts Using Hypothermic Oxygenated Perfusion
S G Michel, G M La Muraglia, M L Madariaga, J S Titus, M K Selig, E A Farkash, J S Allan, L M Anderson, J C Madsen
Annals of Transplantation, 2014; 19:409-416

Organ transport temperature box: multicenter study on transport temperature of organs
D F Horch, T Mehlitz, O Laurich, A Abel, S Reuter, H Pratschke, P Neuhaus, C Wesslau Transplant Proceedings, Vol. 34, Issue 6, 2002 DOI:

Are temperatures attained by donor hearts during transport too cold?
P J Hendry, V M Walley, A Koshal, R G Masters, W J Keon The Journal of Thoracic and Cardiovascular Surgery, Volume 98, Issue 4, 1989 DOI:

Effect of temperature in long-term preservation of vascular endothelial and smooth muscle function
R Ingemansson, A Budrikis, R Bolys, T Sjöberg, S Steen The Annals of Thoracic Surgery, Volume 61, Issue 5, 1996 DOI:

Endothelial dysfunction caused by University of Wisconsin preservation solution in the rat heart: The importance of temperature
The Journal of Thoracic and Cardiovascular Surgery, Volume 104, Issue 6, 1992 P Mankad, Z Slavik, M Yacoub DOI:

Cardiac Transplantation: The Ideal Myocardial Temperature for Graft Transport
W J Keon, P J Hendry, G C Taichman, G W Mainwood The Annals of Thoracic Surgery, Volume 46, Issue 3, 1988 DOI:

Preservation & Transport
Donor heart and lung procurement: A consensus statement
H Copeland, J W Awori Hayanga, A Neyrinck, P MacDonald, G Dellgren, A Bertolotti, T Khuu, F Burrows, J G Copeland, D Gooch, A Hackmann, D Hormuth, C Kirk, V Linacre, H Lyster, S Marasco, D McGiffin, P Nair, A Rahmel, M Sasevich, M Schweiger, A Siddique, T J Snyder, W Stansfield, S Tsui, Y Orr, P Uber, R Venkateswaran, J Kukreja, M Mulligan The Journal of Heart and Lung Transplantation, Vol. 39, Issue 6, 2020 DOI:

Primary Graft Dysfunction
Report from a consensus conference on primary graft dysfunction after cardiac transplantation
J Kobashigawa, A Zuckermann, P Macdonald, P Leprince, F Esmailian, M Luu, D Mancini, J Patel, R Razi, H Reichenspurner, S Russell, J Segovia, N Smedira, J Stehlik, F Wagner The Journal of Heart and Lung Transplantation, Vol. 33, Issue 4, 2014 DOI:

PREDICTA: A Model to Predict Primary Graft Dysfunction After Adult Heart Transplantation in the United Kingdom
S A Singh, S Das De, S Rushton, C Berry, N Al-Attar Journal of Cardiac Failure, Vol. 25, Issue 12, 2019 DOI:

Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors
A Nicoara, D Ruffin, M Cooter, C B Patel, A Thompson, J N Schroder, M A Daneshmand, A F Hernandez, J G Rogers, M V Podgoreanu, M Swaminathan, A Kretzer, M Stafford‐Smith, C A Milano, R R Bartz American Journal of Transplantation, Vol. 18, Issue 6, 2017 DOI:

Incidence, predictors, and outcomes after severe primary graft dysfunction in pediatric heart transplant recipients
E L Profita, K Gauvreau, P Rycus, R Thiagarajan, T P Singh The Journal of Heart and Lung Transplantation, Vol. 38, Issue 6, 2019 DOI: